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How Does Clomid Work for Fertility?

 

Clomid is also known as clomiphene citrate. It’s an oral medication that is often used to treat certain types of female infertility.

Clomid works by making the body think that your estrogen levels are lower than they are, which causes the pituitary gland to increase secretion of follicle stimulating hormone, or FSH, and luteinizing hormone, or LH. Higher levels of FSH stimulate the ovary to produce an egg follicle, or multiple follicles, that will develop and be released during ovulation. High levels of LH stimulate ovulation.

Recommended Dosage

Treatment of the selected patient should begin with a low dose, 50 mg daily (1 tablet) for 5 days. The dose should be increased only in those patients who do not ovulate in response to cyclic 50 mg CLOMID. A low dosage or duration of treatment course is particularly recommended if unusual sensitivity to pituitary gonadotropin is suspected, such as in patients with polycystic ovary syndrome (see WARNINGS; Ovarian Hyperstimulation Syndrome).

The patient should be evaluated carefully to exclude pregnancy, ovarian enlargement, or ovarian cyst formation between each treatment cycle.

If progestin-induced bleeding is planned, or if spontaneous uterine bleeding occurs prior to therapy, the regimen of 50 mg daily for 5 days should be started on or about the 5th day of the cycle. Therapy may be started at any time in the patient who has had no recent uterine bleeding. When ovulation occurs at this dosage, there is no advantage to increasing the dose in subsequent cycles of treatment.

 

Uses

If a woman has irregular cycles, or anovulatory cycles (menstruation without ovulation), Clomid may be tried first. Clomid is often used in treating polycystic ovarian syndrome (PCOS) related infertility

It may also be used in cases of unexplained infertility or when a couple prefers not to use the more expensive and invasive fertility treatments. (However, it's important to remember that the more expensive treatment is sometimes the most appropriate.)

Clomid may also be used during IUI (intrauterine insemination) or IVF procedures. With IVF, Clomid may be used in conjunction with injectable ovulation medications to elicit a stronger response.

 

Benefits

For women who are appropriately treated with Clomid, there are many benefits:

1.         It’s a cost-effective treatment for infertility, especially when compared with other treatments like IVF.

2.         Clomid is an oral medication, which makes it less invasive than other treatments.

3.         It can be prescribed by your OB-GYN or primary care provider, instead of needing to go to a reproductive specialist.

4.         There are relatively few side effects and it’s generally well-tolerated by women who take it.

 

Success Rate

Clomid will jump-start ovulation in 80% of patients, but ovulating doesn't guarantee pregnancy will occur. While Clomid does help many women ovulate, obviously it's not always successful. When Clomid does not result in ovulation, we say the woman is Clomid resistant. (This isn't the same as when Clomid does trigger ovulation but doesn't lead to pregnancy.)


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